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Antisperm antibodies, or ASA, are immune system proteins that destroy sperm. They can be produced when the body mistakes sperm for an invader and triggers the immune system to protect itself. Though rare, antisperm antibodies can be found in semen, blood, or vaginal fluids. The presence of antisperm antibodies can have a negative effect on fertility by impacting sperm count, motility, and sperm-egg interaction.
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