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Systemic lupus erythematosus and Sjogrens syndrome patients frequently have antibodies to the Ro (SSA)-La(SSB) antigen system found in their sera and these antibodies seem to have diagnostic value. In addition to patients with ANA negative SLE who have a pronounced photosensitive dermatitis and may have substantial renal impairment, these antibodies can be found in up to 25% of patients with systemic lupus erythematosus (SLE) without the sicca complex.
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