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When the immune system is unable to discriminate between its own antigens and foreign antigens, anti-dsDNA antibodies are made against the DNA. These autoantibodies harm tissues and organs. Anti-dsDNA in the blood is a strong indicator of an autoimmune condition. Therefore, an anti-dsDNA screening is advised to find these antibodies. Patients with symptoms and signs that are suggestive of systemic lupus erythematosus might use the test to help determine whether they have the disease (SLE). In order to help diagnose lupus, the test is advised after a positive antinuclear antibody test. Additionally, it could be needed to keep tabs on SLE development.
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