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A tissue transglutaminase IgA (tTg-IgG) test is used to help doctors diagnose celiac disease. In this autoimmune disorder, the immune system mistakenly thinks that gluten — a protein in wheat, barley, rye, and oats — is a foreign invader. It makes antibodies that attack an enzyme in the intestines called tissue transglutaminase (tTG). Antibodies (also called immunoglobulins) are proteins that recognize and get rid of germs.
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