Rotavirus infection is the most common and major cause of chronic gastroenteritis in children. Many times, even infants get affected by rotavirus infection. This is also referred as infectious diarrhea, which is common in kids. Rotavirus antigen test involves detection of rotavirus in the feces. The viral infection impact and creates a myriad of responses, from mild to severe. It causes mild clinical infection, acute to severe diarrhea and even dehydration. Rotavirus is one of the major causes of nosocomial infections. In addition to kids, even elders with poor health and immunity suppressed patients, prone to this infection.