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A protein called pregnancy-associated plasma protein-A (PAPP-A) is first created by the placenta as it develops. This protein builds up in the pregnant womans blood throughout a typical pregnancy and continues to rise until birth. PAPP-A, hCG and nuchal translucency tests are used together in the first trimester screening to determine the likelihood that the fetus a pregnant woman is carrying has a chromosomal issue such Down syndrome (trisomy 21) or Edwards syndrome (trisomy 18).
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