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A number of malignant illnesses, such as carcinomas of the pancreas, stomach, gallbladder, colon, ovaries, cervix, and endometrial, have been linked to elevated CA 72-4 levels in serum and plasma. According to recent investigations, gastrointestinal tract and ovarian carcinomas have the highest diagnostic sensitivity levels. Although other benign conditions, such as rheumatic illnesses or ovarian cysts, may also cause elevated CA 72-4 levels, clinical investigations showed that gastrointestinal and ovarian cancers had diagnostic specificity of more than 95%.
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