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The SARS-CoV-2 Spike (S) protein is one of the four major structural proteins of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19. The SARS-CoV-2 Spike protein has a theoretical molecular weight of approximately 180 kDa and consists of a S1 globular head region which contains the N-terminal receptor-binding domain (RBD) and the S2 stem region that contains the C-terminal fusion domain, two heptad regions, a transmembrane domain, and a cytoplasmic tail.
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