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Urine
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The measurement of 3-methylhistidine provides an index of the rate of muscle protein breakdown. Urinary concentration of 3-methylhistidine is a biomarker for skeletal muscle protein breakdown in humans who have been subject to muscle injury. Hence it is a very stable marker of proteolysis of skeletal muscle. 3-Methylhistidine is also a biomarker for meat consumption, especially chicken and consumption of soy products. 3MEH is synthesized from methylation of actin and myosin which are muscle building blocks of human body.
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