Creatine Kinase (CK) also referred to as creatine phosphokinase (CPK) or phosphocreatine kinase is an enzyme in the body that causes the phosphorylation of creatine. Creatine kinase (CK) is found in the skeletal muscle, cardiac muscle, brain, bladder, stomach and colon. The CPK levels can be elevated by muscle diseases or muscle necrosis. CPK leaks into the blood when a muscles tissue is damaged, and as such high levels of CPK is indicative of stress or injury to the heart or other muscles. CPKMM is a very important constituent of active muscle, and it has been shown to increase with any type of muscle trauma, prolonged exercise, in diagnosis, prognosis and treatment of polymyositis, dermatomyositis, Malignant hyperthermia, and in ruling out others such as polymyalgia rheumatic.