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Tests to detect Clostridium difficile (C. difficile or C. diff for short), the genes associated with toxin production, and its toxins are used to help diagnose diarrhea and other conditions and complications caused by toxin-producing C. difficile. There are many infectious and non-infectious causes of acute and chronic diarrhea and this testing may be used to help determine the cause. Clostridium difficile Glutamate Dehydrogenase (GDH) is an enzyme produced in large quantities by all toxigenic and non-toxigenic strains, making it an excellent marker for the organism.
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