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Many HIV tests look for p24 antigen in addition to antibodies to HIV. These are called fourth-generation tests. One distinctive HIV antigen is a viral protein called p24, a structural protein that makes up most of the HIV viral core. High levels of p24 are present in the blood serum of newly infected individuals during the short period between infection and seroconversion, makes p24 antigen assays useful in diagnosing primary HIV infection.
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