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IgG4-related disease is an immune-mediated condition, meaning that it involves the occurrence of disease in organs as the result of a dysregulated immune system. Increasing evidence suggests that IgG4-RD is an autoimmune condition, much like rheumatoid arthritis and systemic lupus erythematosus. The classic IgG4-RD patient is a middle-aged to elderly individual–more likely to be male than female. In rare cases, the disease also affects children.
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