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Anti-Saccharomyces cerevisiae antibodies (ASCA) are protein molecules present in people with inflammatory bowel disease (IBD). This disease involves several problems like significant inflammatory reactions, chronic symptoms, autoimmunity, and tissue damage. ASCA test detects the presence of antibodies in blood and differentiates between Crohn’s disease and ulcerative colitis. Nearly 75% of people who have Crohn’s disease have ASCA in their blood and it could be either IgG or IgA. Since both Crohn’s disease and ulcerative colitis are intestinal disorders, they have similar symptoms and it gets confusing to start the treatment without proper testing. While IgA is the first line of defence and indicates the presence of the condition in the body, IgG indicates the severity of the infection. The test also helps in finding out the type of IBD a person has.
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