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MPL Mutation Analysis - This DNA-based assay tests leukocytes from blood or bone marrow aspirate for mutations in exon 10 of the thrombopoietin receptor (MPL), including codons 505 and 515, using an advanced DNA sequencing method. Mutations at these sites in MPL are associated with myeloproliferative neoplasms, particularly essential thrombocythemia and primary myelofibrosis.
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