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Factor XIII [FXIII] is a heterodimer and circulates in plasma as a pro-transglutaminase consisting of two catalytic A subunits [FXIII-A2] and two non-catalytic B subunits [FXIII-B2] held together by non-covalent bonds. Intracellular Factor XIII including platelet Factor XIII comprises only the FXIII-A subunits and exists as a homodimer of the A subunit [FXIII-A2]. Factor XIII has a number of other functions in addition to the stabilisation of the Fibrin clot and these include the maintenance of pregnancy, bone/cartilage growth and wound healing.
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