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U1 snRNP (U1), in addition to its splicing role, protects pre-mRNAs from drastic premature termination by cleavage and polyadenylation (PCPA) at cryptic polyadenylation signals (PASs) in introns. Anti-U1RNP antibody (anti-U1RNP) is generally known to be a serological marker for mixed connective tissue disease (MCTD)
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